Cellulase Fusion Enzyme
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The glucosidase activity is important because the ...
The glucosidase activity is important because the accumulation of cellobiose inhibits the cellulose degradation. Specifically for the cellulosic fuel producers that require at least three enzymatic activities; combining activities into one fusion enzyme has the potential to reduce enzyme costs by 30% or more. For enzyme manufacturers, bio-fuel has been projected to be a $5 billion enzyme market (Science News, 2008). Currently the cost to convert cellulose material to fuel is about $2.25 per gallon of ethanol. The cost per gallon of ethanol for enzymes to convert plant material to fermentable sugars is $0.10 to $0.50 (Schill, 2009). The enzymatic cost to convert corn into ethanol is ~$0.05 / gallon. The enzymatic cost to convert cellulose biomass is 2X to 10X more. A 30% reduction in enzyme costs could result in reducing yearly operating costs for a single 50 MGPY cellulosic ethanol producer between $300,000 and $5,250,000.
The cellulase fusion enzyme is under development.
The Opportunity
C2 Biotechnologies (C2B), LLC seeks partner to license the marketing, sales and distribution of the amylase fusion enzyme technology. Scientists at C2B have engineered a new cellulase fusion enzyme that combines exocellulase and glicosidase bio-activities into one molecule. The cellulase fusion enzyme was designed to function under temperatures and pH used in yeast fermentation. This property allows cellulose digestion and fermentation to occur at the same time.
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