SMS - Model Vacuum Series - Dynamic Vapor Sorption

1. Temperature :
• Temperature controlled enclosure
• Control range: 20°C to 70°C
• Regulation accuracy: ±0.2°C
• Enclosure also provides anti-condensation protection
2. Weight measurement :
• High Resolution microbalance
• Sample mass: between 1 and 1000mg
• Mass change: ±150mg
• Resolution (precision): 0.1 μg
• Peak to peak noise: ≤ 0.3 μg
3. Pressure measurement :
• 1000 Torr Baratron full scale from 0.01 up to 1000 Torr (standard)
• 10 Torr Baratron: full scale from 0.005 up to 10 Torr (standard)
• Other ranges available upon request (100 and 500 Torr)
• Accuracy: ±0.5 of Reading
• Resolution: 0.01% of full scale
4. Vacuum pressure measurement : Vacuum pressure transducer: full scale from 1×10-8 Torr up to 760 Torr
5. Computer hardware and software : The system is fully automated and controlled by purpose-built software. Data can be analyzed in real time using analysis software.

Key measurement capabilities:

• In-situ sample outgassing at temperatures of up to 400 °C and high vacuum (≤10-6 Torr)
• In-situ drying curves of pharmaceutical materials at various pressures and temperatures
• Real-time adsorption / desorption kinetics
• Adsorption / desorption IsoTherms (T constant, P variable)
• Adsorption / desorption IsoBars (T variable, P constant)
• ‘apparent’ BET (Brunauer, Emmett and Teller) Surface Area
• Diffusion coefficients
• Heat of Adsorption
• Dynamic Competitive Adsorption of two probe molecules (e.g. CO2 – H2O, Toluene – H2O, MeOH – H2O)
• Binary competitive adsorption of one probe molecule at constant loading of other probe molecule
• Multiple adsorption/desorption and sample regeneration cycles

DVS Vacuum offers dynamic or static sorption or co-adsorption experiments from low pressures up to 1bar. The system’s key features are precise control and measure of temperature and pressure while recording the changes in sample mass using high-resolution UltraBalace.

DVS Vacuum uses vacuum produced by a combination of roughing and turbomolecular pumps for its operation – in-situ outgassing of sample up to 400 °C and water or organic vapors generation at the set temperature. The vacuum chamber including sample, pressure transducers, vapor/gas delivery system, and solvent flasks are at thermal equilibrium in a single temperature enclosure allowing smooth operation over the entire temperature range (20-70 °C) without risk of condensation. The system introduces partial pressures of water or organic solvent under vacuum to minimize their impact on the structure of a material. The analyzer measures true water or organic vapor sorption isotherms without unnecessary interference from a carrier gas. In addition, it allows us to study the drying kinetics of pharmaceutical powders.